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Akt Inhibitor VII, TAT-Akt-in
H-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL110-24
A cell-permeable and reversible version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT that displays antitumor properties. Inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells, and tumor growth in syngeneic C57BL/6 mice.
产品信息
Peptide Sequence H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
Form White solid
Formulation Supplied as an acetate salt.
Primary Target Akt
Primary Target IC50 50 µM
Secondary target PKA, PKC, PDKl
Molar mass 3412.9
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility H2O
Chemical formula C152H239N55O36
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic |