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Akt Inhibitor III
A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
产品信息
Form White solid
Primary Target Akt
Molar mass 568.7
Packaged under inert gas 是的
Purity ≥98% by NMR
Solubility DMSO
Chemical formula C28H57O9P
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |