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AG 825
4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50 = 0.35 µM) relative to HER1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
产品信息
Form Yellow solid
Primary Target HER2
Primary Target IC50 0.35 µM
Secondary target HER1 (IC50 = 19 µM)
Molar mass 397.5
Protect from Light 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C19H15N3O3S2
CAS number 149092-50-2
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |