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Adenophostin A, Hexasodium Salt
One of the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R (EC50 = 14.7 nM for Ca2+ release from permeabilized hepatocytes). Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to enzymatic degradation.
产品信息
Form White solid
Molar mass 801.2
Hygrocopic 是的
Purity ≥90% by HPLC
Solubility H2O
Chemical formula C16H20N5O18P3 · 6Na
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |