A77 1726 N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide Leflunomide metabolite that blocks TNF-dependent NF-κB activation and gene expression. Inhibits the activity of dihydroorotate dehydrogenase (DHO-DH; IC50 = 220 nM). Reported to reduce IFN-γ-induced expression of iNOS in L929 fibroblasts. Inhibits IL-1β-induced activation of COX-2 and PGE2 synthesis (IC50 = 130 nM) in A549 cells. A cell-permeable, reversible, and substrate competitive inhibitor that inhibits the IL-2-induced tyrosine phosphorylation of JAK1 and JAK3. 产品信息 Form White solid Primary Target DHO-DH Primary Target IC50 220 nM Secondary target IL-1b-induced activation of COX-2 and PGE2 synthesis (IC50 = 130 nM) in A549 cells Molar mass 270.2 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility DMSO Chemical formula C12H9F3N2O2 CAS number 108605-62-5 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Carcinogenic / Teratogenic 安全标示 S Phrase S: 22-36 Do not breathe dust. Wear suitable protective clothing. R Phrase R: 40 Limited evidence of a carcinogenic effect.