Angiotensin II, Human Plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60c-src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells. Peptide Sequence H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH Form White to off-white solid Primary Target adenylate cyclase activity Molar mass 1046.2 Hygrocopic 是的 Purity ≥98% by HPLC Sold on the basis of peptide content 是的 Solubility H2O or 5% Acetic Acid Chemical formula C50H71N13O12 RTECS BW2165000 CAS number 4474-91-3 Merck USA index 14 651 Storage -20°C Ship Ambient Temperature Only Standard Handling