Calpeptin Benzyloxycarbonylleucyl-norleucinal A cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells Peptide Sequence Z-Leu-Nle-CHO Form White to off-white solid Primary Target calpain-1 Primary Target IC50 52 nM Secondary target calpain-2 (IC50 = 34 nM), papain (IC50 = 138 nM) Packaged under inert gas 是的 Cell permeable 是的 Purity ≥94% by HPLC Chemical formula C20H30N2O4 CAS number 117591-20-5 Storage -20°C Ship Ambient Temperature Only Standard Handling