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Rat / Mouse FGF-21 ELISA Kit
Description:
Rat / Mouse FGF-21 ELISA Kit
Qty/Pk:
96-well strip plate
Background Information:
Recent studies have demonstrated that fibroblast growth factor 21 (FGF-21), a liver derived protein, is able to increase glucose uptake, as well as lower plasma triglyceride levels in an insulin-independent manner. FGF-21 suppresses glucagon release, thereby increasing insulin sensitivity, and reduces the amount of insulin production by pancreatic β-cells. Unlike insulin, which works in a rapid, hormone-like manner, FGF-21 activity requires several hours, indicating changes in gene expression. No significant weight gain was observed when FGF-21 was injected into animals, and mice that had been genetically engineered to overexpress FGF-21 weighed less and had less adipose tissue than the normal controls.
Although considerable progress has been made in the understanding of the pathobiology of type 2 diabetes, as well in the development of new compounds for the treatment of diabetic patients, this disease remains a major global health concern. Consequently, Millipore is pleased to offer the Rat/Mouse FGF-21 ELISA kit for the quantification of FGF-21 in rat and mouse serum and plasma samples. The insulin-independent activities of FGF-21, as well as the absence of the weight gain effects of insulin, thiazolidinediones and other anti-diabetic drugs, distinguish it from current insulin-sensitizing drugs, making it a promising therapeutic.
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Applications:
This Rat / Mouse FGF-21 ELISA Kit is used to measure & quantify FGF-21 levels in Metabolism & Inflammation & Immunology research.
Key Applications:
ELISA
Application Notes:
This is a 3-hour assay requiring 20 μL (in duplicate) of rat sample or 10µl (in duplicate) of mouse sample.
Species Reactivity:
Rat
Mouse
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Linearity of Dilution:
Please contact Technical Service for this information
Standard Curve Range:
50 – 12000 pg/mL
Product Name:
Rat / Mouse FGF-21 ELISA Kit
Specificity:
Cross-reactivity to Human FGF-21: 39%
No significant cross-reactivity to the cytokines and metabolic hormones tested was observed.
Analytes Available:
FGF-21
Precision, %:
Intra-assay: < 10%
Inter-assay: < 8 %
Detection Methods:
Colorimetric
Fluorescent
Accuracy:
Spike Recovery: 85 – 102 % |