|
Goat Anti-Mouse IgM Antibody, μ chain, HRP conjugate
Close
REFERENCES
High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.
Cerf, Emilie, et al. (2011) FASEB J., 25: 1585-95 (2011)
Modulation of cellular adhesion by glycoengineering.
Laila Dafik,Marc d'Alarcao,Krishna Kumar (2010) Journal of medicinal chemistry.53
Species Reactivity Key Applications Host Format Antibody Type
M ELISA, WB Goat HRP Polyclonal Antibody
Description:
Goat Anti-Mouse IgM Antibody, μ chain, HRP conjugate
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Based on immunoelectrophoresis, the antibody reacts with the heavy chain portion of IgM. No reactivity with IgG or non-immunoglobulin serum proteins was detected, but cross reactivity with IgM from other species may be detected.
Background Information:
IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences.
Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type.
View All »
Species Reactivity:
Mouse
Purification Method:
Immunoaffinity purified
Presentation:
Freeze dried powder, made from liquid containing 0.01M phosphate buffered saline, 0.25M sodium chloride, 15 mg/mL bovine serum with no preservatives. Reconstitute in 2mL deionized water, centrifuge if not clear. Prepare a working dilution fresh for each day.
Storage Conditions:
Maintain lyophilized product at 2-8°C for up to 12 months. After reconstitution the product is stable for several weeks at 2-8°C as an undiluted liquid. For extended storage after reconstitution, add an equal volume of glycerol to make a final concentration of 50% glycerol followed by storage at -20°C in undiluted aliquots for up to 12 months. Please note the concentration of protein (and buffer salts) will decrease to one-half of the original after the addition of glycerol. Avoid repeated freeze/thaw cycles.
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
ELISA
Western Blotting
Brand Family:
Chemicon
Product Name:
Goat Anti-Mouse IgM Antibody, μ chain, HRP conjugate
Concentration:
0.8-1.0 mg/mL
Antibody Type:
Polyclonal Antibody
Qty/Pk:
2 mL
Format:
HRP
Host:
Goat
Applications:
This Goat anti-Mouse IgM Antibody, μ ch |