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H-Ras cDNA (activated) in pUSEamp
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PRODUCT FAMILY INFORMATION
RAS Antibodies, Kits, Proteins & Plasmids
Millipore’s RAS antibodies, kits, and plasmids are high quality, validated tools for research. These are based on the expertise of Upstate & Chemicon. See below for Millipore’s Ras G-protein products.
Millipore’s RAS antibodies, kits, plasmids and proteins are high quality, validated tools for RAS research. See below for data and references for Millipore’s RAS products. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
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Description:
H-Ras cDNA (activated) in pUSEamp
Trade Name:
Upstate (Millipore)
Qty/Pk:
5 µg
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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UniProt Summary:
FUNCTION: SwissProt: P01112 # Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
SIZE: 189 amino acids; 21298 Da
SUBUNIT: In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus.
PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
DISEASE: SwissProt: P01112 # Defects in HRAS are the cause of Costello syndrome [MIM:218040]; also known as faciocutaneoskeletal syndrome. Costello syndrome is a rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities. & Mutations which change positions 12, 13 or 61 activate the potential of c-ras to transform cultured cells and are implicated in a variety of human tumors. & Defects in HRAS are a cause of bladder cancer [MIM:109800]. & Defects in HRAS are also the cause of oral squamous cell carcinoma (OSCC).
SIMILARITY: SwissProt: P01112 ## Belongs to the small GTPase superfamily. Ras family.
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Brand Family:
Upstate
UniProt Number:
P01112
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Gene Symbol:
HRAS
c-bas/has
H-Ras-1
N-ras
p21ras
c-H-ras
RASH1
H-RasIDX
Ha-Ras
K-ras
CTLO
HRAS1
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Product Name:
H-Ras cDNA (activated) in pUSEamp
Entrez Gene Number:
NM_005343.2
NM_176795.2 |