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NAD Cofactor
Description:
NAD Cofactor
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 mg
Product Overview:
Description: β-nicotinamide adenine dinucleotide hydrate
FW: 663.4
Use: Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.
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Applications:
Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.
Key Applications:
Histone Deacetylase Assay (HDAC)
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
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UniProt Summary:
COFACTOR: Binds 1 magnesium or manganese ion per subunit (By similarity).
SIZE: 366 amino acids; 39592 Da
SUBUNIT: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 (By similarity).
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: SwissProt: P50213 ## Belongs to the isocitrate and isopropylmalate dehydrogenases family.
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Brand Family:
Upstate
Presentation:
lyophilized powder
UniProt Number:
P50213
Storage Conditions:
1 year at room temperature
Gene Symbol:
IDH3A
NAD
Product Name:
NAD Cofactor
Entrez Gene Number:
NM_005530.2 |