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S6 Kinase Substrate Cocktail
Description:
S6 Kinase Substrate Cocktail
Trade Name:
Upstate (Millipore)
Qty/Pk:
1 mL
Key Applications:
Kinase Assay
Application Notes:
For use in kinase assays.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
UniProt Summary:
FUNCTION: SwissProt: Q9UK32 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium (By similarity).
SIZE: 745 amino acids; 83872 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
PTM: Autophosphorylated on Ser-389, as part of the activation process (By similarity).
SIMILARITY: SwissProt: Q9UK32 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
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Brand Family:
Upstate
Presentation:
20mM MOPS, pH 7.2, 25mM β-glycerophosphate, 5mM EGTA, 1mM sodium orthovanadate, 1mM dithiothreitol.
Storage Conditions:
1 year at -20°C
Gene Symbol:
RPS6KA1
pp90RSK1
HU-1
RSK-1
MAPKAPK1A
p90S6K
RSK1
RSK
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Product Name:
S6 Kinase Substrate Cocktail
UniProt Number:
Q15418
Q15349
P51812
O75676
O75582
Q9UK32
P23443
Q9UBS0
Q96S38
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Entrez Gene Number:
NM_001006665.1
NM_002953.3 |