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4G10® Platinum/4A4 Phosphopack
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PRODUCT FAMILY INFORMATION
Phosphoserine Antibodies
Millipore’s phosphoserine antibodies, including the popular 4A4 clone, demonstrate sensitivity and detect multiple serine phosphorylations on numerous substrates. See below for pSer antibodies.
Millipore’s phosphoserine antibody demonstrates specificity against Phosphoserine. See below for data and references for Millipore’s phosphoserine antibodies. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
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Phosphotyrosine Antibodies
Millipore’s phosphotyrosine antibodies, including the popular 4G10 clone, demonstrate sensitivity and detect multiple tyrosine phosphorylations on numerous substrates. See below for pTyr antibodies.
Millipore’s phosphotyrosine antibody demonstrates specificity against Phosphotyrosine. See below for data and references for Millipore’s phosphotyrosine antibodies. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
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Phosphoserine/Threonine Antibodies & Kits
Approximately 400 of the 518 kinases in the human genome are serine/threonine specific protein kinases. Millipore offers antibodies for your phospho-Ser/Thr research needs, such as those below.
Approximately 400 of the 518 kinases in the human genome are serine/threonine specific protein kinases and approximately 40 serine/threonine specific protein phosphatases are encoded by the human genome.
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Phosphotyrosine Signaling Solutions
Study tyrosine phosphorylation using Millipore's specific and sensitive antibodies, including the popular clone 4G10®, and new 4G10 Platinum, available in various conjugations. See below for more.
Study tyrosine phosphorylation using Millipore's specific and sensitive antibodies, including the popular clone 4G10®, and new 4G10 Platinum, available in various conjugations. See below for more.
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Species Reactivity Key Applications Host Format Antibody Type
WB, IF, FC, IHC, ELISA, ICC Mouse null null
Description:
Phosphorylation Explorer Pack Sample Kit
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Trade Name:
Upstate (Millipore)
Molecular Weight:
Dependent upon the molecular weight of the tyrosine phosphorylated protein being detected.
Modifications:
Phosphorylation
Clone:
4G10® Platinum and 4A4
Background Information:
4G10® Platinum
The development of the anti-phosphotyrosine, clone 4G10® in 1989 was a monumental discovery for researchers. 4G10® was the first and is the best single monoclonal antibody for the detection tyrosine phosphorylation. 4G10® is well known for its sensitivity and its ability to detect multiple tyrosine phosphorylations on numerous substrates. It has been validated by thousands of scientific and medical researchers in virtually every application and tyrosine target over the past 2 decades. To improve on something that hundred have tried and no one has succeeded, we pooled 4G10® with the next most highly regarded anti-phosphotyrosine, clone PY20 to make 4G10® Platinum. PY20 itself is a very poor substitute for 4G10®, but its additive effect allow for a greater level of detection on more substrates that even 4G10® alone was not capable of.
4A4
The identification of protein phosphorylation as a regulatory mechanism originated from studies by Fischer and Krebs in the mid 1950s that later earned them the 1992 Nobel prize. It is the major mechanism for the regulation of diverse cellular processes including cell division, protei |