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Rac2 Activation Assay Kit
Description:
Rac2 Activation Assay Kit
Trade Name:
Upstate (Millipore)
Qty/Pk:
30 assays
Applications:
Non-radioactive Rac2 Activation Assay Kit can be used to precipitate Rac2-GTP from cell lysates & detection by a Rac2 specific monoclonal antibody.
Key Applications:
Affinity Binding Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
UniProt Summary:
FUNCTION: SwissProt: P15153 # Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Seems to be involved in the regulation of the NADPH oxidase.
SIZE: 192 amino acids; 21429 Da
SUBUNIT: Interacts with DOCK2, which may activate it.
SUBCELLULAR LOCATION: Cytoplasm. Note=Membrane-associated when activated.
TISSUE SPECIFICITY: Hematopoietic specific.
DISEASE:SwissProt: P15153 # Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome [MIM:608203].
SIMILARITY: SwissProt: P15153 ## Belongs to the small GTPase superfamily. Rho family.
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Brand Family:
Upstate
Gene Symbol:
RAC2
p21-Rac2
GX
Gx
EN-7
HSPC022
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Product Name:
Rac2 Activation Assay Kit
Quality Assurance:
Routinely evaluated by Immunoprecipitation of Rac2-GTP from HL-60 cells that had been loaded with GTPγS.
Components:
Rac/cdc42 Assay Reagent (PAK1 PBD, agarose) (Cat.# 14-325)
Anti-Rac2 (Cat.# 07-604)
Mg2+ Lysis/Wash Buffer, 5X (Cat.# 20-168)
100X GTPγS, 10mM (Cat.# 20-176)
100X GDP, 100mM (Cat.# 20-177)
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UniProt Number:
P15153
Packaging:
Kit capacity: 30 assays
Entrez Gene Number:
NM_002872.3 |