Vincristine . sulfate Microtubule inhibitor Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins. Causes aberrant tubulin polymerization. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Posttranscriptionally downregulates HIF-1α expression. Product Specification Alternative Name: VCR . sulfate, Leukocristine . sulfate Formula: C46H56N4O10 . H2SO4 MW: 825.0 . 98.1 CAS: 2068-78-2 MI: 14: 9986 RTECS: OH6340000 Purity: ≥98% (Assay) Appearance: White to off-white powder. Hazard: MAY BE TERATOGENIC. TOXIC. Solubility: Soluble in water (25mg/ml) or methanol. Long Term Storage: -20°C Use/Stability: Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. Handling: Protect from light and moisture.