Paclitaxel Ultra-pure; stabilizes microtubules Antitumor agent. Stabilizes microtubules and lowers the critical concentration for tubulin polymerization. Reversibly binds to polymerized tubulin. Inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK) are involved in Paclitaxel-induced apoptosis. Product Specification Formula: C47H51NO14 MW: 853.9 Source: Isolated from the bark of the Pacific Yew tree (Taxus brevifolia) CAS: 33069-62-4 MI: 14: 6982 Purity: ≥98% Appearance: White solid. Hazard: IRRITANT. TOXIC. Solubility: Soluble in ethanol, DMSO or acetonitrile. Long Term Storage: -20°C Use/Stability: Store solutions at -20°C for up to 6 months. Handling: Keep cool and dry.
