The MRN-ATM pathway is essential for sensing the signaling from DNA double-strand breaks. Mirin is an inhibitor of MRN discovered using a forward chemical genetic screen. It prevents MRN-dependent activation of ATM without affecting ATM protein kinase activity and it inhibits Mre11-associated exonuclease activity. IC50=66μM. It abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Product Specification Formula:C10H8N2O2S MW:220.3 CAS:299953-00-7 Purity:95% (TLC) Appearance:Yellow solid. Solubility:Soluble in DMSO (25mg/ml) or DMF (25mg/ml). Long Term Storage:-20°C