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热销正品|Garcinol

产品编号: BML-GR343-0050     查看说明书
产品名称: 热销正品|Garcinol  .0   订购此产品 
供应商: Biomol
规格: 50 mg
目录价: 5001.75
库存状态: 期货
CAS编号: 78824-30-3
应用范围: 生化实验
种属来源:
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Garcinol|Biomol BML-GR343-0050|原装热销 
产品说明:
Formula: C38H50O6
MW: 602.8
CAS: 78824-30-3
Purity: ≥95% (TLC)
Appearance: Yellow Solid
Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml) or dimethylformamide (25mg/ml) or water (nil)
Long Term Storage: -20°C
简介:
Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7µM) and PCAF (IC50=5µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. It induces apoptosis in HeLa cells (100µM) where it down regulates global gene expression. Acetylation of histone H4 by p300 was more sensitive to inhibition by garcinol compared with that of H3. more
Histone H4 acetylation was completely inhibited at 1 M while acetylation of H3 was not abolished at 20 µM1

保存条件: -20°C
说明书地址: 点击查看详细
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