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Cell permeable, amphiphilic, mast cell degranulating tetradecapeptide. Stimulates glycogenolysis and phospholipase D2 (PLD2) activity. Alters G-proteins in brain membranes. Directly activates G proteins by a mechanism analogous to that of G protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Stimulates exocytosis and phosphoinositide breakdown in a variety of cells. Inhibits calmodulin, and activates PLA2. Acts as a mitogen in Swiss 3T3 cells and stimulates pertussis toxin-sensitive arachidonate release without phosphoinositide breakdown.
Product Specification
Sequence:H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
Formula:C70H131N19O15
MW:1478.9
Source:Synthetic. Originally isolated from wasp venom (Vespula lewisii).
CAS:72093-21-1
Formulation:Lyophilized.
Purity:≥98% (HPLC)
Solubility:Soluble in water (1 mg/ml) or 100% ethanol.
Long Term Storage:-20°C |