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Replaces Prod. #: ALX-380-004
Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Selectively blocks signaling leading to the activation of p70/85 S6 kinase. Enhances apoptosis. Activator of autophagy both in vitro and in vivo.
Product Specification
Alternative Name: Sirolimus, AY-22,989, RAPA, Rapamune
Formula: C51H79NO13
MW: 914.2
CAS: 53123-88-9
MI: 14: 8114
RTECS: VE6250000
Purity: ≥98% (TLC)
Appearance: Off-white or yellow solid.
Hazard: HARMFUL.
IRRITANT.
Solubility: Soluble in chloroform, DMSO (25mg/ml) or methanol.
Long Term Storage: -20°C
Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
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