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Replaces Prod. #: ALX-380-093
Antibiotic. Inhibitor of HSP90. Interacts with the C-terminal ATP-binding domain of HSP90 in contrast to the benzoquinone ansamycins 17-AAG (Prod. No. BML-EI308), geldanamycin (Prod. No. BML-EI280), herbimycin A (Prod. No. BML-EI227) and the chemically unrelated radicicol (Prod. No. BML-EI285), which bind to the N-terminal ATP-binding site of HSP90. Inhibitor of DNA gyrase. Useful for the production of positively supercoiled plasma DNA, targeting the nucleotide-binding site of gyrase B. Inhibits retrovirus RNA-dependent DNA polymerase. Potent inhibitor of ADP ribosylation. Inhibits LPS-induced production of pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6 and IL-10. Inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins. Reverses etoposide resistance in non-P-glycoprotein expressing multidrug resistant (MDR) tumor cell lines. Inducer of CD38 on cells of the myelomonocytic lineage. Forms ion channels in lipid bilayers. Inhibitor of breast cancer resistance protein (BCRP)
Product Specification
Alternative Name: Albamycin, Streptonivicin, N-[7-[[3-O-Aminocarbonyl-6-deoxy-5-C-methyl-4-O-β-L-lyxo-hexapyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)benzamide
Formula: C31H35N2O11 . Na
MW: 611.6 . 23.0
CAS: 1476-53-5
MI: 14: 6722
RTECS: RD5425000
Purity: ≥90%
Appearance: White solid.
Hazard: HARMFUL.
Solubility: Soluble in water (100mg/ml), ethanol or DMSO.
Long Term Storage: -20°C
Handling: Protect from light. |