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Replaces Prod. #: ALX-380-005
Ascomycin is a close structural analog of FK506 and is a potent immunosuppressant. It binds to FKBP (FK506-binding protein) and suppresses its proline rotamase activity. The ascomycin-FKBP complex inhibits calcineurin, a type 2B phosphatase.
Product Specification
Formula: C43H69NO12
MW: 792
Source: Isolated from Streptomyces sp.
CAS: 11011-38-4
Purity: ≥95% (HPLC)
Appearance: Off-white solid
Hazard: HARMFUL.
Solubility: Soluble in DMSO (25mg/ml)
Long Term Storage: -20°C
Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
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