Ac-ESMD-CHO

Ac-ESMD-CHO
Caspase and granzyme inhibitor
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide.
Product Specification
Alternative Name: Caspase-8 inhibitor (aldehyde), Granzyme B inhibitor (aldehyde)
Sequence: Ac-Glu-Ser-Met-Asp-CHO
Formula: C19H30N4O10S
MW: 506.5
Formulation: Lyophilized.
Peptide Content: 70-90%.
Purity: ≥99% (HPLC)
Appearance: White powder.
Solubility: Soluble in distilled water.
Long Term Storage: -20°C
Use/Stability: Use always fresh solutions.
Handling: Keep under inert gas. Keep cool and dry.