Ac-DEVD-CHO

Ac-DEVD-CHO
Caspase-3 inhibitor
Replaces Prod. #: BML-P410
Highly specific, potent and reversible inhibitor of caspase-3. Ki<1nM for purified caspase-3. IC50=0.2nM for PARP cleavage in cultured human osteosarcoma cell extracts. In contrast, the caspase-1 (ICE) specific inhibitor YVAD-CHO has a Ki=12µM for caspase-3 and IC50>10µM for PARP cleavage in osteosarcoma cell extracts. The DEVD sequence is based on PARP cleavage site Asp-216 for caspase-3.
Product Specification
Alternative Name: Caspase-3 inhibitor (aldehyde), Caspase-7 inhibitor (aldehyde)
Sequence: Ac-Asp-Glu-Val-Asp-CHO
Formula: C20H30N4O11
MW: 502.5
CAS: 169332-60-9
Formulation: Lyophilized.
Peptide Content: 70-90%.
Purity: ≥95% (HPLC)
Solubility: Soluble in distilled water or DMSO.
Reconstitution: Add 0.2ml DMSO per 1mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material.
Long Term Storage: -20°C
Use/Stability: Stock solutions should be divided into aliquots and stored at -20°C. Solutions are stable for at least 1 month when stored at -20°C in the dark and protected from moisture.
Handling: Keep under nitrogen. Keep cool and dry.