mTOR (human FRB Domain), pAb

mTOR (human FRB Domain), pAb
mTOR (FKBP12-rapamycin associated protein (FRAP)) is one of a family of proteins involved in cell cycle progression, DNA recombination,
and DNA damage detection. It has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. FKBP12-rapamycin-binding
(FRB) domain is a conserved 11kDa region necessary for FKBP12-rapamycin binding. FRB is one of several functional domains of mTOR: HEAT
 (Huntington elongation factor 1A-protein phosphatase 2A-A subunit-TOR); FAT (FRAP, ATM, TTRAP2); PIKK (PI3-kinase-related kinase); RD
(regulatory domain); and FATC (FAT, C terminal).
Product Specification
Alternative Name: mTOR (human FKBP12-rapamycin-binding domain)
Host: Rabbit
Immunogen: Recombinant human mTOR (FKBP12-rapamycin-binding (FRB) domain).
UniProt ID: P42345
Application: Chromatin Immunoprecipitation
                Immunocytochemistry
                Western Blot (1:2’000)
Specificity: Recognizes the FRB domain of fusion proteins expressed in Saccharomyces cerevisiae (see H. Haruki, et al. 2008) and the human FRB domain of mTOR.
Formulation: Lyophilized from neat serum containing sodium azide.
Reconstitution: Reconstitute with 50µl water.
Long Term Storage: +4°C