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BMP-14 (GDF-5/CDMP-1), human recombinant
A protein involved in bone and cartilage development
Product Overview
Alternate Names / Synonyms: human BMP-14, BMP-14, BMP14, BMP 14, h-BMP-14, rh-BMP-14, recombinant human BMP-14, recombinant BMP-14, BMP
Gene Symbol: GDF5
Accession #: X80915
Gene ID: 8200
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized from 10 mM Sodium Citrate, pH 3.5.
Molecular Weight: 27 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1-2 µg/ml.
Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.
Storage Temp.: -20°C
Shipping: Blue ice
Background Information: BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-14 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development. Recombinant human BMP-14 is a 27 kDa homodimeric protein consisting of two 120 amino acid polypeptide chains.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans. |