TFAM Antibody
Product Image
Click to enlarge
Product OverviewAntibody Target: TFAM
Alternative Name: Transcription factor A, MtTF1, TCF6, TCF6L2, mtTFA
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Immunogen: Synthetic peptide corresponding to residues surrounding amino acid 225 of rat TFAM
Accession#: Q91ZW1
Gene ID: 83474
Appearance: Colorless liquid
Concentration: 0.5 mg/ml
Formulation: 100 µg (0.5mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Purification: Affinity purified
Species Reactivity: rat
Application: Western blot
Application & Usage: Western blotting (0.5-4µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 27 kDa band from rat kidney tissue lysate. Reactivity to other species has not been tested.
Storage Temp.: -20 °C
Shipping: gel pack
Background Descriptions: Transcription factor A mitochondria (TFAM) is an important activator of mitochondrial DNA transcription and replication. Studies in mice have shown that TFAM is required to regulate the mitochondrial genome copy number and is important for embryonic development. TFAM has been associated with mitochondrial disorder which includes ocular myopathy and muscular wasting in humans. Kearns-Sayre syndrome was shown in mouse model when expression of the gene was eliminated by targeted disruption in heart and muscle cells.
Handling: The antibody solution should be gently mixed before use.
Usage: For Research Use Only! Not to be used in humans. |