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PUMA/bbc3 Antibody
Product Overview
Antibody Target: PUMA
Alternative Name: JFY1; PUMA; FLJ42994; BBC3
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Immunogen: Synthetic peptide mapping to the C-terminus of human PUMA.
Accession#: Q9BXH1
Gene ID: 27113
Appearance: Colorless liquid
Concentration: 0.5 mg/ml
Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit anti-PUMA polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification: Affinity purified
Species Reactivity: human, mouse
Application: Western Blot & Immunofluorescence
Application & Usage: Western blotting (0.5-4 µg/ml) and immunofluorescence (2-4 µg/ml). However, the optimal dilution conditions should be determined individually.
Storage Temp.: -20 °C
Shipping: gel pack
Background Descriptions: PUMA (p53 upregulated modulator of apoptosis) is one of the pro-apoptotic Bcl-2 family members which are also transcriptional targets of p53. PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Handling: The antibody solution should be gently mixed before use.
Usage: For Research Use Only! Not to be used in humans. |