|
DL-α-Lipoic Acid
Cayman Chemical Item Number 10005728
Description
DL-α-lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.1↗,2↗,3↗ DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.
1 Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).
2 Randle, P.J. Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14(4) 263-283 (1998).
3 Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The role of lipoic acid in the treatment of diabetic polyneuropathy*. Drug Metab Rev 29(4) 1025-1054 (1997).
Synonyms Thioctic acid
Formal Name 1,2-dithiolane-3-pentanoic acid
CAS Number 1077-28-7
Molecular Formula C8H14O2S2
Formula Weight 206.3
Formulation A crystalline solid
Purity >95%
λmax 203, 333 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES OC(=O)CCCCC1SSCC1
InCHI Code 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InCHI Key AGBQKNBQESQNJD-UHFFFAOYSA-N |