原装现货Anti-human, mouse MyD88 (C-terminus) polyclonal 50 ug

Anti-human, mouse MyD88 (C-terminus) polyclonal 50 ug
Anti-Human/Mouse MyD88 Purified
Also known as: Myeloid differentiation primary response protein MyD88
Clone: Polyclonal
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-6223
Description: The polyclonal antibody reacts with human and mouse MyD88; the antibody was raised against residues 279-296 of human MyD88 and recognizes human and mouse antigens. MyD88, a myeloid differentiation primary response gene, is expressed in a variety of tissues and functions as an adapter molecule in the IL-1 signaling pathway involved in the inflammatory responses induced by cytokines and LPS. MyD88 associates with and recruits IRAK to the IL-1 receptor. Dominant negative mutants of MyD88 attenuate IL-1R-mediated NF-κB activation. MyD88 also functions as a regulator molecule for IL-18 receptor and human Toll receptor family. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to LPS.