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Functional Aspects:
CD166 is also referred to as activated leukocyte cell adhesion molecule (ALCAM) and functions as a CD6 ligand. In addition to activated leukocytes it is expressed on activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells and in sweat and sebaceous glands. It may function in the binding of T and B cells to activated leukocytes, T cell development in the thymus ad neurite extension of neurons. Interestingly, CD166 is upregulated in metastasizing melanoma cell lines. |