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Functional Aspects:
CD13 antigen acts as a zinc-binding metalloprotease that plays a role in cell surface antigen presentation by clipping the N-terminal amino acids from MHC class II-bound antigens. It is also a receptor for coronaviruses. CD13 is expressed on granulocytes, monocytes and their precursors. It is found on non-hematopoietic cells such as endothelial cells, epithelial cells, certain renal areas, fibroblasts, brain cells, bone marrow, osteoclasts and cells lining the bile canaliculi. In research applications, this antibody may be useful as a marker for most acute myeloid leukemias and a number of acute lymphoid leukemias. |