|
V1377 SIGMA
Vinblastine sulfate salt
powder, ≥96% (HPLC)
Synonym: VLB, Vincaleukoblastine sulfate salt
CAS Number 143-67-9
Empirical Formula (Hill Notation) C46H58N4O9 · H2SO4
Molecular Weight 909.05
assay ≥96% (HPLC)
Biochem/physiol Actions
Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.
form powder
color white
mp 267 °C (dec.)(lit.)
solubility H2O: soluble10 mg/mL
DMSO: soluble50 mg/mL
absorption A1mM/214 nm, ethanol 53.7
A1mM/259 nm, ethanol 16.2
A1mM/270 nm, 0.1 M phosphate buffer 14
storage temp. 2-8°C |