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Active Human Caspases Group III
Set of recombinant proteases involved in apoptosis
Product Overview
Alternate Names / Synonyms: Caspases Group III, Active Human
Gene Symbol: CASP6 CASP8 CASP9 CASP10a
Accession #: CASP6- P55212 CASP8- Q14790 CASP9- P55211 CASP10- Q92851
Gene ID: CASP6- 839 CASP8- 841 CASP9- 842 CASP10- 843
Source: E. coli
Appearance: Lyophilized
Physical Form Description: Lyophilized powder
Molecular Weight: N/A
Purity by SDS-PAGE: N/A
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS containing 15% glycerol
Storage Temp.: -70°C
Shipping: Gel Pack
Background Information: Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The Group III recombinant caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VEID-pNA (for caspase-6), IETD-pNA (for caspase-8 & -10) and LEHD-pNA (for caspase-9), respectively.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans. |