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CXCR4 Antibody
Product Overview
Antibody Target: CXCR4
Alternative Name: chemokine C-X-C motif receptor 4, chemokine receptor 4
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Immunogen: E. coli-expressed rat CXCR4
Accession#: AAL47855
Gene ID: 17902281
Appearance: Colorless liquid
Concentration: 0.5 mg/ml
Formulation: 100 µg (0.5 mg/ml) protein A purified rabbit anti-CXCR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.01% thimerosal.
Purification: Affinity purified
Species Reactivity: mouse, rat
Application: Western blot/, Neutralization, Flow cytometry
Application & Usage: Western blot analysis (1 µg/ml), neutrolization and FACS analysis. However, the optimal conditions should be determined individually.
Storage Temp.: -20 °C
Shipping: gel pack
Background Descriptions: CXCR4 (fusin) is a member in the seven-transmembrane domain G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been shown to be the co-receptor for HIV-1 binding to CD4 through the viral envelope glycoprotein gp120. In other cases, CXCR4 can function as the only receptor for the interaction of HIV-2 with CD4 and host cells. A mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.
Handling: The antibody solution should be gently mixed before use.
Usage: For Research Use Only! Not to be used in humans. |