Murine flt-3-Ligand

flt3-Ligand, murine recombinant
A member of a small family of growth factors that stimulate the proliferation of hematopoietic cells
Product Overview
Alternate Names / Synonyms: Murine flt-3-Ligand, flt-3-Ligand, flt3-Ligand, flt 3-Ligand,m-flt-3-Ligand, rm-flt-3-Ligand, recombinant murine flt-3-Ligand, recombinant flt3-Ligand
Gene Symbol: Flt3-L
Accession #: P49772
Gene ID: 14256
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized with no additives.
Molecular Weight: 16.4 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg (0.1EU/μ) of flt3-Ligand
Biological Activity: Determined by the dose-dependent proliferation of mouse AML5 cells and is typically 5-8 ng/ml.
Reconstitution Instructions: Reconstitute in water to a concentration of 0.1 – 1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: Flt3-Ligand belongs to a small group of growth factors that regulate proliferation of early hematopoietic cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant form is the transmembrane which is biologically active on the cell surface. The proteolytically cleaved transmembrane isoform generates a soluble form, which is also biologically active. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand alone cannot stimulate proliferation, but synergizes well with other CSFs and interleukins to induce growth and differentiation. Recombinant murine flt3-Ligand is a 16.4 kDa protein containing 144 amino acid residues.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.