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Tyrphostin AG 490
Product Overview
Product Name: Tyrphostin AG 490
Alternate Name/Synonyms: 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide, AG 490
Description: Selectively inhibits EGF receptor auto-phosphorylation (IC₅₀ = 100 µM) and selectively inhibits DNA synthesis and cell growth; induces apoptosis. A JAK2 inhibitor. Blocks growth of leukemia cells in vivo and in vitro.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 133550-30-8
Molecular Formula: C₁₇H₁₄N₂O₃
Molecular Weight: 294.31
Purity: ≥99%
Solubility:DMSO (100 mM) and ETOH (20 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
InChi: InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChi Key: TUCIOBMMDDOEMM-RIYZIHGNSA-N
PubChem CID: 5328779
MDL Number: MFCD00236452
USAGE: For Research Use Only! Not For Use in Humans. |