Active Human Caspase-7

Caspase-7, human recombinant
A cysteine protease involved in apoptosis
Product Overview
Alternate Names / Synonyms: Active Human Caspase-7, Active Caspase-7, Caspase-7 Enzyme, Recombinant caspase-7, human caspase-7, human caspases, active caspases
Gene Symbol: CASP7
Accession #: P55210
Gene ID: 840
Source: E. Coli.
Appearance: Lyophilized powder
Physical Form Description: Lyophilized powder
Molecular Weight: N/A
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: > 25000 units/mg
Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Storage Temp.: -70°C
Shipping: gel pack
Background Information: Caspase-7 (also know as Mch3, ICE-LAP3, CMH-1) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-7 also exists in cells as an inactive proenzyme. During apoptosis procaspase-7 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of caspase-7 consists of large and small subunits which associate to form the active enzyme. Active caspase-7 has been shown involving in the proteolysis of PARP (poly ADP-ribose polymerase), an enzyme that is involved in DNA repair and genomic maintenance. The recombinant active human caspase-7 was expressed in E. coli. The active caspase-7 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-DEVD-pNA (Cat. #1008-200) or Ac-DEVD-AFC (1007-200).
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.