Active Human Caspase-4

Caspase-4, human recombinant
A cysteine protease involved in apoptosis
Product Overview
Alternate Names / Synonyms: Active Human Caspase-4, Active Caspase-4, Caspase-4 Enzyme, Recombinant caspase-4, human caspase-4, human caspases, active caspases
Gene Symbol: CASP4
Accession #: P49662
Gene ID: 837
Source: E. Coli.
Appearance: Lyophilized powder
Physical Form Description: Lyophilized powder
Molecular Weight: N/A
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: > 5000 units/mg
Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Storage Temp.: -70°C
Shipping: gel pack
Background Information: Caspase-4 (also know as Ich-4, ICErelII, TX) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-4 exists in cells as an inactive proenzyme which is matured by proteolysis to yield large and small subunits. The active caspase-4 is a heterotetramer consisting of two large and two small subunits. To date the mechanism of caspase-4 activation and roles of caspase-4 in apoptosis are poorly understood. The recombinant active human caspase-4 was expressed in E. coli. The active caspase-4 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-WEHD-pNA (Cat. #1102-200) or Ac-WEHD-AFC (1101-200).
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.