Active Human Caspase-2

Caspase-2, human recombinant
A cysteine protease involved in apoptosis
Product Overview
Alternate Names / Synonyms: Active Human Caspase-2, Active Caspase-2, Caspase-2 Enzyme, Recombinant caspase-2, human caspase-2, human caspases, active caspases
Gene Symbol: CASP2
Accession #: P42575
Gene ID: 835
Source: E. Coli.
Appearance: Lyophilized powder
Physical Form Description: Lyophilized powder
Molecular Weight: two large (19 kDa) and two small (12 kDa) subunits
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Storage Temp.: -70°C
Shipping: gel pack
Background Information: Caspase-2 (also know as Ich-1, Nedd-2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-2 also exists in cells as an inactive proenzyme. During apoptosis pro-caspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed active caspase-2 is a heterotetramer consisting of two large (19 kDa) and two small (12 kDa) subunits.The recombinant active human caspase-2 was expressed in E. coli. The active caspase-2 preferentially cleaves caspase-2 substrates (e.g., VDVAD-AFC or VDVAD-pNA) and is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-VDVAD-pNA (Cat. #1072-200) or Ac-VDVAD-AFC (1071-200).
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.