Caspase-8 Inhibitor Z-IETD-FMK

Caspase-8 Inhibitor Z-IETD-FMK
Product Overview
Product Name: Caspase-8 Inhibitor Z-IETD-FMK
Alternate Name/Synonyms: Z-IETD-FMK, Caspase-8 Inhibitor, Z-IETD-fluoromethylketone
Description: A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)
Peptide Sequence: Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK
Appearance: Liquid
Formulation: DMSO (2 mM)
CAS Number: N/A
Molecular Formula: C₃₀H₄₃FN₄O₁₁
Molecular Weight: 654.7
Purity: >99% by HPLC
Solubility:N/A
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChi: InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)
InChi Key: PHLCQASLWHYEMX-UHFFFAOYSA-N
PubChem CID: 44135212
MDL Number: MFCD01861686
USAGE: For Research Use Only! Not For Use in Humans.