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T8931 SIGMA Thyrotropic hormone from bovine pituitary 2 IU/mg protein Synonym: TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands CAS Number: 9002-71-5 packaging vial of 10 IU storage temp. 2-8°C Gene Information cow ... TSHB(281552) human ... TSHR(7253) Biochem/physiol Actions Thyrotropic hormone or Thyroid stimulating hormone (TSH) belongs to glycoprotein hormone family. The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines. Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic. Quality Contains phosphate buffer salts Application Thyrotropic hormone from bovine pituitary can be used for TSH stimulation test for assessing the thyroid gland function after NTI induction.1 The product was injected in 4-week-old male C57BL/6J and CBA/N mice for studying the thyrotropin involvement in photoperiodic signal transduction.2
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