中文名称：黄曲霉素B1
英文名称：Aflatoxin B1
分 子 式：C17H12O6
分 子 量：312.27
CAS号：1162-65-8
适用范围:
1.食品、农产品检测；
2.毒理分析研究；
3.动物免疫学研究。
A6636 SIGMA
Aflatoxin B1 from Aspergillus flavus
CAS Number :1162-65-8
Empirical Formula (Hill Notation): C17H12O6
Molecular Weight: 312.27
biological source from Aspergillus flavus
assay ≥98% (TLC and HPLC)
storage temp. 2-8°C
Application
Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products.
Biochem/physiol Actions
Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR).
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