产品介绍:
二氢睾酮（dihydrotestosteroneC19H30O2）。亦称17β－羟基-5α-雄[甾]烷-3-酮、5α－二氢睾酮、5α－DHT、或雄烷酮（stanorone）。是睾酮的双键在5α处被还原的甾醇。对附属腺（前列腺、精囊腺等），起着所谓的真的雄性激素的作用。在附属性腺的细胞中存在着形成该甾醇的5α-氢化酶。该甾醇和受体蛋白质在细胞内结合成的复合体进入附属腺的细胞核中，促进新的蛋白质合成。显示出比睾酮稍强的雄性激素作用。5β-体虽在肝脏、鸡冠等中以睾酮形态存在，但是没有雄性激素的作用。5α－二氢睾酮由于3α-羟基甾醇脱氢酶的作用而代谢成为5α-雄烷-3α－17β-二醇排出体外。
Sigma相关产品资料:
Sigma A8380 5α-Androstan-17β-ol-3-one ≥97.5%
Synonym:17β-Hydroxy-5α-androstan-3-one, 4,5α-Dihydrotestosterone, Androstanolone, Stanolone
CAS Number:521-18-6
Linear Formula: C19H30O2
Molecular Weight:290.44
Beilstein Registry Number:2056371
EC Number:208-307-3
MDL number:MFCD00003667
PubChem Substance ID:24891337
Description
Biochem/physiol Actions Anabolic steroid. Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.
性质
assay ≥97.5%
drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
Gene Information human ... AR(367), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)
rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)
mouse ... Esr1(13982)