Sigma相关产品资料：
Sigma S0130 Streptozocin
≥75% α-anomer basis, ≥98% (HPLC), powder
Synonym: Streptozotocin, N-(Methylnitrosocarbamoyl)-α-D-glucosamine
CAS Number: 18883-66-4
Linear Formula: C8H15N3O7
Molecular Weight: 265.22
Beilstein Registry Number: 2060675
EC Number: 242-646-8
MDL number: MFCD00006607
PubChem Substance ID: 24899428
Description
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Related Keywords Streptozotocin, N-(Methylnitrosocarbamoyl)-alpha-D-glucosamine, STRZ, STZ, U-9889, Zanosar, U 9889, Streptozocinum, Streoptozocinium, NSC-85998, NRRL 2697, NC160_041900, Estreptozocina, C07313, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, streptozocin, induced diabetes, Methylnitrosocarbamoy
Application Streptozocin is used to induce Type 1 diabetes for medical research.
General description Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
Other Notes Mixed anomers
Biochem/physiol Actions An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
性质
assay ≥75% α-anomer basis ≥98% (HPLC)
form powder
color white to off-white
mp 121 °C (dec.)(lit.)
storage temp. −20°C
订购 动物模型原理 造膜前的喂养 高脂饲料 预实验重要性 常给药剂量 配置溶液 能否使用其他溶液配置缓冲液 禁食和血糖的联系 腹腔注射和尾部注射的区别 注射前有那些操作步骤 &n