产品说明:SB203580也写作SB 203580或SB-203580，是一种常用的p38 MAPK抑制剂。SB203580可以通透细胞，抑制p38 MAPK(p38 MAP kinase)，抑制后续MAPKAP Kinase-2和MAPKAP Kinase-3的激活。通过抑制p38 MAPK，SB203580可以有效抑制一些炎症因子(如IL-1β、TNF-α)诱导的部分信号转导。SB203580选择性抑制p38 MAPK，IC50为600 nM；对于JNK/SAPK和p44/42 MAPK(即Erk1/2)无显著的抑制作用，IC50仅为100 μM。
SB203580分子量为377.43，分子式为C21H16N3FOS，CAS Number：152121-47-6。
MERCK相关产品资料：
559389 SB 203580 ( SB 203580 )
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
产品信息
Form Thin film
Primary Target P38MAPK
Primary Target IC50 34 nM
Secondary target THP-1 (IC50 = 500-100 nM)
Molar mass 377.4
Protect from Light Yes
Cell permeable Yes
Purity ≥98% by HPLC