供应硫酸博莱霉素/Blenoxane/Bleo/Blexane
Bleomycin sulfate from Streptomyces verticillus
BioChemika, for fluorescence, mixture of bleomycin sulfate salts, lyophilized, powder, white
Description
| Application | Recommended for use as a selection agent at 10-100 μg/ml. |
| Other Notes | DNA degradation1,2; Action mechanism, minireview3 |
| Biochem/physiol Actions | An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis. |
Properties
| grade | for fluorescence |
| product line | BioChemika |
| form | powder |
| quality | lyophilized |
| color | white |
| solubility | H2O: 20 mg/mL, clear, colorless |
| cation traces | Cu: ≤1000 mg/kg |
| storage temp. | 2-8°C |
Safety