英文名:Dactinomycin, Actinomycin D, ACTD
中文名: 更生霉素, 放线菌素D
CAS: 50-76-0
说明:放线菌素D（Dactinomycin D）又称更生霉素，分子中含有一个苯氧环结构，通过它连接两个等位的环状肽链。此肽链可与DNA分子的脱氧鸟嘌呤发挥特异性相互作用，使dactinomycin D嵌入DNA双螺旋的小沟中，与DNA形成复合体，阻碍RNA多聚酶的功能，抑制RNA的合成，特别是mRNA的合成。属于周期非特异性药物。一次静脉注射给药后，很快从血浆消除，多数药物以原形经胆汁和尿液排出。抗瘤谱较窄，用于肾母细胞瘤、绒毛膜上皮癌、横纹肌肉瘤和神经母细胞瘤等。
Sigma相关产品资料：
Sigma A1410 Actinomycin D from Streptomyces sp.,
~98% (HPLC)
Synonym: Actinomycin C1, Actinomycin IV, Dactinomycin
CAS Number: 50-76-0
Linear Formula: C62H86N12O16
Molecular Weight: 1255.42
Beilstein Registry Number: 605235
EC Number: 200-063-6
MDL number: MFCD00005033
PubChem Substance ID: 24890541
Description
Biochem/physiol Actions An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Caution Hygroscopic and light sensitive.
性质
biological source from Streptomyces sp.
assay ~98% (HPLC)
form powder
color red, powder red to orange
mp 251-253
solubility DMSO: 1 mg/mLethanol: soluble
storage temp. 2-8°C